Zitat:
The subject of insulin resistance is extremely complex and there are many facets that we have yet to figure out.
First of all insulin resistance in someone with a normal phenotype has different manifestations and effects than insulin resistance in someone with specific polymorphisms that have significant effects on carbohydrate, fat and protein metabolism, and predispositions for certain conditions, including diabetes and the metabolic syndrome.
Secondly, insulin resistance as shown by the effects on Glut4 receptors and glucose absorption, may or may not be associated with insulin resistance as far as the effects of insulin on fat and protein metabolism. In some cases insulin resistance as far as glucose metabolism, especially if the effects on protein metabolism are spared, can be a very good thing for someone on a low carb, high protein diet.
As far as the effects of insulin resistance on glycogen storage, in some cases there may be differential effects on glycolysis, glycogenolysis and glycogen formation which may lead to increased rather than decreased glycogen levels in muscle and/or liver.
...it's important to know that insulin resistance, because of its complexity, can actually be a good thing in certain conditions, and can be used to maximize body composition. That's because insulin resistance can be manipulated so that it applies differently to different body tissues and metabolic processes.
Insulin resistance in glucose metabolism, which can allow increased use of free fatty acids, and therefore body fat, as fuel, can be present along side of insulin sensitivity in amino acid transport and protein synthesis, which maximizes muscle mass, and with insulin resistance to fat tissue, which increases lipolyis and decreases lipogenesis.
PS: Principal actions of insulin: 