4-Hydroxy Isoleucine?

[king8080]

kann mir jemand Auskunft ueber die Wirkung/Nebenwirkungen von 4-Hydroxy Isoleucine geben?

[king8080]

Kennt das Zeug niemand...bitte um Hilfe?

[Solaris]

Eine Aminosäure, die in den Samenkörnern des Bockshornklee zu finden ist.

Eine Wirksamkeit in irgendeiner Form ist nicht nachgewiesen.

Gruss Micha

[rantanplan]

Eine Wirksamkeit in irgendeiner Form ist nicht nachgewiesen.

Gruss Micha

Das würde ich so nicht sagen.

Amino Acids. 2005 Feb;28(1):71-6.

The addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthesis after exercise.

Ruby BC, Gaskill SE, Slivka D, Harger SG.

Department of Health and Human Performance, The University of Montana, Missoula, Montana 59812-1825, USA. brent.ruby@mso.umt.edu

The purpose of this study was to determine the effects of ingesting an oral supplement containing 4-Hydroxyisoleucine (4-OH-Ile, isolated from fenugreek seeds [Trigonella foenum-graecum]) with a glucose beverage on rates of post-exercise muscle glycogen resynthesis in trained male cyclists. Following an overnight fast (12 hr), subjects completed a 90-minute glycogen depletion ride after which a muscle biopsy was obtained from the vastus lateralis. Immediately and 2 hours after the muscle biopsy, subjects ingested either an oral dose of dextrose (Glu) (1.8 g.kg BW(-1)) or 4-OH-Ile supplement (Glu+4-OH-Ile, including 2.0 mg.kg(-1) 4-OH-Ile with the same oral dose of dextrose) with a second muscle biopsy 4 hours after exercise. Post exercise muscle glycogen concentration was similar for both trials. Overall, there was a significant increase in glucose and insulin concentrations from time 0 throughout the majority of the 4-hour recovery period, with no significant differences between the two trials at any time point. Although muscle glycogen concentration significantly increased from immediately post exercise to 4 hr of recovery for both trials, the net rate of muscle glycogen resynthesis was 63% greater during Glu+4-OH-Ile (10.6+/-3.3 vs. 6.5+/-2.6 g.kg wet wt.(-1).hr.(-1) for the Glu+4-OH-Ile and Glu trials, respectively). These data demonstrate that when the fenugreek extract supplement (4-OH-Ile) is added to a high oral dose of dextrose, rates of post-exercise glycogen resynthesis are enhanced above dextrose alone.

Am J Physiol. 1999 Oct;277(4 Pt 1):E617-23.

4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties.

Broca C, Gross R, Petit P, Sauvaire Y, Manteghetti M, Tournier M, Masiello P, Gomis R, Ribes G.

Unite Mixte de Recherche 9921 du Centre National de la Recherche Scientifique, Faculte de Medecine UPRES EA 1677, 34060 Montpellier, France. broca2zeus.sc.univ-montp1.fr

We have recently shown in vitro that 4-hydroxyisoleucine (4-OH-Ile), an amino acid extracted from fenugreek seeds, potentiates insulin secretion in a glucose-dependent manner. The present study was designed to investigate whether 4-OH-Ile could exert in vivo insulinotropic and antidiabetic properties. For this purpose, intravenous or oral glucose tolerance tests (IVGTTs and OGTTs, respectively) were performed not only in normal animals but also in a type II diabetes rat model. During IVGTT in normal rats or OGTT in normal dogs, 4-OH-Ile (18 mg/kg) improved glucose tolerance. The lactonic form of 4-OH-Ile was ineffective in normal rats. In non-insulin-dependent diabetic (NIDD) rats, a single intravenous administration of 4-OH-Ile (50 mg/kg) partially restored glucose-induced insulin response without affecting glucose tolerance; a 6-day subchronic administration of 4-OH-Ile (50 mg/kg, daily) reduced basal hyperglycemia, decreased basal insulinemia, and slightly, but significantly, improved glucose tolerance. In vitro, 4-OH-Ile (200 microM) potentiated glucose (16.7 mM)-induced insulin release from NIDD rat-isolated islets. So, the antidiabetic effects of 4-OH-Ile on NIDD rats result, at least in part, from a direct pancreatic B cell stimulation.

Diabetes. 1998 Feb;47(2):206-10.

4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion.

Sauvaire Y, Petit P, Broca C, Manteghetti M, Baissac Y, Fernandez-Alvarez J, Gross R, Roye M, Leconte A, Gomis R, Ribes G.

Laboratoire de Recherche sur les Substances Naturelles Vegetales, Universite Montpellier II, France.

We report the characterization of a new insulinotropic compound, 4-hydroxyisoleucine. This amino acid has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties. 4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range of 100 micromol/l to 1 mmol/l, through a direct effect on isolated islets of Langerhans from both rats and humans. The stimulating effect of 4-hydroxyisoleucine was strictly glucose dependent; indeed, ineffective at low (3 mmol/l) or basal (5 mmol/l) glucose concentrations, the amino acid potentiated the insulin secretion induced by supranormal (6.6-16.7 mmol/l) concentrations of glucose. In addition, in the isolated perfused rat pancreas, we could show 1) that the pattern of insulin secretion induced by 4-hydroxyisoleucine was biphasic, 2) that this effect occurred in the absence of any change in pancreatic alpha- and delta-cell activity, and 3) that the more glucose concentration was increased, the more insulin response was amplified. Moreover, 4-hydroxyisoleucine did not interact with other agonists of insulin secretion (leucine, arginine, tolbutamide, glyceraldehyde). Therefore, we conclude that 4-hydroxyisoleucine insulinotropic activity might, at least in part, account for fenugreek seeds' antidiabetic properties. This secretagogue may be considered as a novel drug with potential interest for the treatment of NIDDM.

[Solaris]

ok, formulieren wirs um :

Die Aminosäure könnte vielleicht in Zukunft eine Hilfe für Diabetiker sein, es bedarf noch genauerer Forschung.
Die 3 Studien, neben einigen Infos aus Heilpraktiker-Datenbanken hatte ich auch gefunden.

Wirksamkeit als Supplement ist wie bei vielen andren auch, nicht bewiesen.

Die beiden älteren Studien beziehen sich auf in-vitro und Tests an Ratten, die Studie aus 2005
lässt Fragen offen. Wie trainiert waren die Radler, wieviele waren es, in welchem Alter,
Ergebnisse reproduzierbar, usw, usw.

Gruss
Micha

[bb86]

hab das zeug in meinem fenuplast drinnen von peak.ag . 4-hydroxy-isoleucine soll die bauchspeichdrüse anregen mehr insulin zu produzieren.