...results suggest that a very-low-carbohydrate diet favors loss of fat. Water may account for some of the initial rapid weight loss, but it appears that fat loss accelerates and lean tissue is preserved over longer periods. There is no evidence that prolonged very-lowcarbohydrate
diets cause chronic dehydration. (...)
During prolonged fasting or adherence to a very-low-carbohydrate diet, whole-body metabolism gradually shifts toward obtaining a greater percentage of energy from lipid sources, which can result in the production of ketone bodies in the liver. Clinically, ketone body production indicates that lipid metabolism has been accelerated and that all the enzymes involved in metabolic pathways of lipid metabolism (eg, lipolysis, fatty acid transport, beta-oxidation, and ketogenesis) are operational.
During starvation or periods when carbohydrate intake is very low, ketone bodies serve as an alternative oxidative fuel for peripheral tissues to spare carbohydrate and protein. In this sense, ketone bodies could be considered the perfect fuel for dieters.
Catabolism of protein is reduced by ketones, which probably explains the preservation of lean tissue observed during verylow-carbohydrate diets. The small amount of glucose required by the brain and red blood cells can easily be met via gluconeogenesis from protein and fat.
(...)
Collectively, these studies indicate that very-low-carbohydrate diets alter the effects of insulin on oxidative and nonoxidative glucose disposal, favoring storage of glucose as glycogen in muscle. They also appear to prevent insulin-stimulated inhibition of lipid oxidation.
Data from these studies do not support the notion that very-low-carbohydrate diets exacerbate the risk of type 2 diabetes and insulin
resistance; rather, they actually show a potential favorable effect as evidenced by decreased basal endogenous glucose production and
improved insulin-stimulated nonoxidative glucose disposal.
Lesezeichen