+ + + Elzi Volk über Fischöl + + +
I advocate fish oil for several reasons, some of which are highly
individual. Omega-3 FAs are well documented to modulate cell function
and metabolism, with the following effects:
1) ratio of n-6, n-3 and cholesterol influences structural and
functional properties of cell membranes. n-3 increases fluidity and
possibly protein/receptor sensitivity in the membranes.
2) n-3s compete with n-6 to produce anti-inflammatory eicosanoids.
3) production and release of several cytokines and other immune system
mediators are suppressed.
4) n-3s upregulate UCP1 in adipose tissue.
5) n-3 downregulates fatty acid synthase in white adipose tissue
The overall response to n-3 supplementation is:
1) improves various pathophysiological states, such as cardiovascular
disease, psoriasis, inflammatory conditions
2) improves post-injury and post-operative response, both stress and
immune status.
3) alters lipogenic activity in adipose tissue with a decrease in fat
mass in both animal and human subjects.
4) increases glucose clearance by upregulating GLUT4 transport
(although I suspect that may be more a function of incorporation of
GLUT4 transporters into the membrane).
5) possibly counteracting the muscle insulin resistance induced by
high muscle TG content (a source of muscle tissue insulin resistance
in obese people)
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