Coffein und Cortisol

[DEAD/LIFTER]

Zitat aus dem Superslow-Forum:

... Coffein ist Cortisolerhöhend
Cortisol oder Stress =kein oder wenig Schlaf
Coffein braucht 9Std bis es vom Körper abgebaut ist.
Lang schlafen und ein niederer Stoffwechsel + wenig Cortisol verlängert das Leben

Ich bin beim herunstöbern über diesen Beitrag gefallen. Ich habe ein bissle gegoogelt und nichts Stichhaltiges darüber gefunden inwieweit der Cortisolausstoß durch Koffein prozentual gefördert wird. Die Quantität würde mich interessieren. Falls jemand dazu Quellen nennen knann würde ich mich freuen.

Vielleicht ist es zu vernachlässigen! Auf einigen Foren wird aber gar von +40 % gesprochen, bei einer Gabe von lediglich 200mg Coffein. Jedoch sind das ziemlich willkürliche Behauptungen. 40% unter Belastung? Nach der Belastung? Im Ruhezustand? Dies wird nicht geklärt ...

Wer weiß mehr?

[rantanplan]

Vielleicht ist es zu vernachlässigen!

...ist zu vernachlässigen!

Mehr zum Thema z.B.: http://jcem.endojournals.org/cgi/reprint/85/6/2170.pdf

Ninety minutes after caffeine ingestion, there was an increase in plasma epinephrine and cortisol concentrations (P , 0.01 vs. baseline)...

...oder hier:

Pharmacol Biochem Behav. 1996 Nov;55(3):365-9.

Stress-like adrenocorticotropin responses to caffeine in young healthy men.

Lovallo WR, Al'Absi M, Blick K, Whitsett TL, Wilson MF.

Veterans Affairs Medical Center, Department of Psychiatry, University of Oklahoma Health Sciences Center, USA.

The effects of oral caffeine (3.3 mg/kg, equivalent to 2-3 cups of coffee) on plasma adrenocorticotropin (ACTH) and cortisol (CORT) were tested in 47 healthy young men at rest in a double-blind, placebo-controlled, crossover study. Following caffeine, ACTH was significantly elevated at all times from 30 min to 180 min, and CORT was elevated from 60 min to 120 min (Fs > or = 8.4, ps < 0.01). Peak increases relative to placebo were: ACTH, 33% (+5.2 pg/ml) and CORT, 30% (+2.7 micrograms/dl) at 60 min postcaffeine. The results suggest that caffeine can activate important components of the pituitary-adrenocortical response in humans during the resting state. Caffeine's known ability to increase CORT production appears at least partly due to an increase in ACTH release at the pituitary.

...andererseits:

Clin Pharmacol Ther. 1984 Sep;36(3):402-7.

Neuroendocrine effects of caffeine in normal subjects.

Spindel ER, Wurtman RJ, McCall A, Carr DB, Conlay L, Griffith L, Arnold MA.

In double-blind crossover experiments, we examined the effects of oral caffeine (250 or 500 mg) added to decaffeinated coffee on plasma hormone levels in adults who normally consume one to three cups of coffee a day. In one experiment, 250 mg (about 4 mg/kg) caffeine was given to men; in two other experiments, 500 mg (8 mg/kg) was given to both sexes. Caffeine, 500 mg, elevated plasma levels of beta-endorphin-like immunoreactivity in both men and women but had no significant effect on plasma levels of cortisol, thyroid-stimulating hormone, growth hormone, prolactin, or triiodothyronine in men nor on plasma levels of prolactin or cortisol in women. The 250-mg dose induced no significant changes in plasma levels of any of the hormones measured. We conclude that the threshold for caffeine's endocrine effects is higher than that for its behavioral effects.

Greenway schreibt in einer Übersichstarbeit zum Thema Ephedrin+Koffein (Obes Rev. 2001 Aug;2(3):199-211):

Caffeine in an oral dose of 250mg increased free fatty acids and glucose, but not cortisol levels, in obese and lean humans compared with a water placebo with each subject acting as his own control.

Gruß

[DEAD/LIFTER]

Sehr gut, und besten Dank!

MfG ... T-1000 ...