Some research in cell culture has indicated that combining creatine and sodium may additionally enhance creatine uptake via the manipulation of increasing the gradient in which the creatine transporter CreaT1 functions[1].

1 Odoom JE, Kemp GJ, Radda GK: The regulation of total creatine content in a myoblast cell line. Mol Cell Biochem 1996, 158:179-188.
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