Tribulus + Creatine + Vanadyl Sulfat

[overdrive73]

Hallo Leute,

was haltet Ihr von diesem Angebot hier ? Ist natürlich wieder das Beste was es gibt !

http://62.159.107.115/j.cfm?i=270751&k=87138

[fhees]

super angebot ich würde auf jeden fall zugreifen.m double you ist eine nahrungsergänzungsfirma und das tribulus von Ihnen ist extrem stark!!!

[rantanplan]

Vanadylsulfat ist offenbar wirkungslos (möglicherweise sogar kontraproduktiv):

Int J Sport Nutr. 1996 Dec;6(4):382-90.

The effect of oral vanadyl sulfate on body composition and performance in weight-training athletes.

Fawcett JP, Farquhar SJ, Walker RJ, Thou T, Lowe G, Goulding A.

School of Pharmacy, University of Otago, Dunedin, New Zealand.

The effects of oral vanadyl sulfate (VOSO4) (0.5 mg/kg/day) on anthropometry, body composition, and performance were investigated in a 12-week, double-blind, placebo-controlled trial involving weight-training volunteers. Performance was assessed in the treatment (VS) and placebo (P) groups using 1 and 10 repetitions maximum (RM) for the bench press and leg extension. Thirty-one subjects completed the trial, with 2 VS subjects withdrawing because of apparent side effects. There were no significant treatment effects for anthropometric parameters and body composition during the trial. Both groups had significant improvements in performance but the only significant effect of treatment was a Treatment x Time interaction in the 1 RM leg extension (p = .002), which could have arisen because the VS group had a lower performance at baseline in this test. It was concluded that oral vanadyl sulfate was ineffective in changing body composition in weight-training athletes, and any modest performance-enhancing effect requires further investigation.

Am J Physiol. 1997 Jan;272(1 Pt 1):C156-62.

Insulin-mimetic agents vanadate and pervanadate stimulate glucose but inhibit amino acid uptake.

Tsiani E, Abdullah N, Fantus IG.

Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

The protein tyrosine phosphatase (PTP) inhibitors vanadate and pervanadate (pV) exert insulin-like biologic effects. In cultured differentiated rat L6 skeletal muscle cells, vanadate and pV stimulated 2-deoxy-D-[3H]glucose uptake in a dose- and time-dependent manner. There was no increase in maximum stimulation by additional insulin. In contrast, whereas insulin stimulated [14C]methylaminoisobutyric acid (MeAIB) uptake, basal uptake was inhibited by vanadate and pV. Insulin-stimulated MeAIB uptake was also inhibited in a dose-dependent manner and completely abolished by 5 mM vanadate or 0.1 mM pV. The inhibitory effect on basal MeAIB uptake was associated with a decrease in transporter affinity and a small decrease in maximum transport capacity, whereas the insulin-stimulated increase in maximum transport capacity was completely inhibited. Inhibition of MeAIB uptake by vanadate and pV was not blocked by cycloheximide, and oubain did not inhibit uptake. Vanadate also inhibited amino acid deprivation-stimulated MeAIB uptake. Insulin-stimulated MeAIB uptake was also inhibited in rat hepatoma cells. Thus vanadate and pV mimic insulin to stimulate glucose uptake but inhibit system A amino acid uptake. The relative inhibitory concentrations of vanadate and pV suggest that the mechanism may involve PTP inhibition.

http://www.diabetesnet.com/vanad.php

Obvious toxic effects from vanadium coumpounds are usually seen in lab animals at minimum doses of 2.5 to 7.5 mg/kg/day. Although this is higher than typical over-the-counter doses of 30 mg to 60 mg per day, the difference between this dose and toxic doses for animals is not reassuring. For instance, someone who weighs 60 kg. (132 lbs.) and takes 60 mg. a day, their intake would be 1.0 mg/kg/day, or 40% of a dose believed to have shortterm toxic effects in animals. It should also be noted that inhibition of protein synthesis can be seen at much lower doses than those required to produce a toxic effect.